Human Reproduction Update, Vol.3, No.6 pp.533-540, 1997
© European Society of Human Reproduction and Embryology 1997; all rights reserved
Symposium: reproduction in baboons. Some reproductive studies in the baboon
Department of Obstetrics & Gynecology, The Ohio State University Medical Center, Fifth Floor Means Hall, 1654 Upham Drive, Columbus, OH 43210-1228, USA
Abstract
A captive colony of baboons has been used for three decades for various reproductive studies where application of findings to human therapeutics was desired. The characteristics of the menstrual cycle in baboons are very similar to those of women, except that of the baboon is slightly longer and there is a lower luteal phase concentration of oestradiol. The duration of pregnancy in baboons is about two-thirds that of humans but patterns of oestrogen and progesterone secretion are virtually identical. The principal oestrogen produced by the pregnant baboon is oestrone, while oestriol is the most abundant in human pregnancies. Chorionic gonadotrophin (CG) is elevated significantly only in the first trimester of a baboon pregnancy, while human pregnancy concentrations of this hormone are about one-third of the first trimester level in the second and third trimesters. Breeding success of baboons in captivity depends on care being taken to cull infertile animals from the colony prior to commencing matings. Under optimal conditions, fertility rates can reach nearly 80%. Female baboons have been successfully used to gain insights into antifertility effects of contraceptive vaccines directed against CG, spermatozoa and ovum antigens. Extensive use of the colony for developing a human chorionic gonadotrophin (HCG) antifertility vaccine has been invaluable for progress in this field. Other pharmaceuticals and devices have been successfully tested in baboons, but costs and mandated regulations for the management of these non human primates have made their current use in meaningful studies extremely difficult.
Key words: baboons/contraceptive vaccines/hormone profiles/menstrual cycle/pregnancy
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  T. M. D'Hooghe, A. Nyachieo, D. C. Chai, C. M. Kyama, C. Spiessens, and J. M. Mwenda Reproductive research in non-human primates at Institute of Primate Research in Nairobi, Kenya (WHO Collaborating Center): a platform for the development of clinical infertility services? ESHRE Monogr, July 1, 2008; 2008(1): 102 - 107. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Garcia, P. C Lee, and L. Rosetta Impact of social environment on variation in menstrual cycle length in captive female olive baboons (Papio anubis) Reproduction, January 1, 2008; 135(1): 89 - 97. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. N. T. Meeusen, J. Walker, A. Peters, P.-P. Pastoret, and G. Jungersen Current Status of Veterinary Vaccines Clin. Microbiol. Rev., July 1, 2007; 20(3): 489 - 510. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. B. Baart, E. Martini, M. J. Eijkemans, D. Van Opstal, N. G.M. Beckers, A. Verhoeff, N. S. Macklon, and B. C.J.M. Fauser Milder ovarian stimulation for in-vitro fertilization reduces aneuploidy in the human preimplantation embryo: a randomized controlled trial Hum. Reprod., April 1, 2007; 22(4): 980 - 988. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. M D'Hooghe, N. P. Nugent, S. Cuneo, D. C. Chai, F. Deer, S. Debrock, C. M. Kyama, A. Mihalyi, and J. M. Mwenda Recombinant Human TNFRSF1A (r-hTBP1) Inhibits the Development of Endometriosis in Baboons: A Prospective, Randomized, Placebo- and Drug-Controlled Study Biol Reprod, January 1, 2006; 74(1): 131 - 136. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Wu, M. B. Zelinski, D. K. Ingram, and M. A. Ottinger Ovarian Aging and Menopause: Current Theories, Hypotheses, and Research Models Experimental Biology and Medicine, December 1, 2005; 230(11): 818 - 828. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Julian, A. C. Enders, A. T. Fazleabas, and D. D. Carson Compartmental distinctions in uterine Muc-1 expression during early pregnancy in cynomolgous macaque (Macaca fascicularis) and baboon (Papio anubis) Hum. Reprod., June 1, 2005; 20(6): 1493 - 1503. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. K. Langat and J. S. Hunt Do Nonhuman Primates Comprise Appropriate Experimental Models for Studying the Function of Human Leukocyte Antigen-G? Biol Reprod, November 1, 2002; 67(5): 1367 - 1374. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R.G. Edwards and H. K. Beard Is the success of human IVF more a matter of genetics and evolution than growing blastocysts? Hum. Reprod., January 1, 1999; 14(1): 1 - 6. [Full Text] [PDF]
|
|